February 11, 2015
by Sayer Ji
(GreenMedInfo.com) According to the Centers for Disease Control and Prevention (CDC), “Immunity to a disease is achieved through the presence of antibodies to that disease in a person’s system.”[i] This, in fact, is the main justification for using vaccines to “boost” immunity, and a primary focus of vaccine research and development.
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And yet, newly published research has revealed that in some cases no antibodies are required for immunity against some viruses.
Published in the journal Immunity in March, 2011, and titled, “B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity,” researchers found that mice infected with vesicular stomatitis virus (VSV) can suffer fatal invasion of their central nervous system even in the presence of high concentrations of “neutralizing” antibodies against VSV.[ii]
The researchers found that while B-cells were essential for surviving a systemic VSV infection through the modulation of innate immunity, specifically macrophage behavior, the antibodies they produce as part of the adaptive immune response were “neither needed nor sufficient for protection.” These findings, according to the study authors, “…contradict the current view that B cell-derived neutralizing antibodies are absolutely required to survive a primary cytopathic viral infection, such as that caused by VSV.”
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