May 04, 2015
(GreenMedInfo.com) The Position Against This Potentially Harmful Practice and Open Invitation for Its Proponents to Articulate Substantiation
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Introduction
Vitamin D3 (cholecalciferol) is unique in nutritional science for its impressive safety, low cost, and wide range of clinical applications. The breadth of its clinical applications provides evidence of the importance of this nutrient/hormone in a wide range of physiologic functions, including calcium absorption and bone health, maintenance of gut mucosal integrity, maintenance of muscle strength, anti-inflammatory benefits, modulation of NFkB, antirheumatic and anti-autoimmune benefits, immunosupportive and anti-infection benefits, anti-cancer benefits, cardioprotection, neuroprotection, and ability to prevent deficiency-induced musculoskeletal pain, weakness, and seizures. In 2004, the current author lead the writing of an important review paper for the integrative medicine and functional medicine communities in Alternative Therapies in Health and Medicine, and this paper sought to effect a “paradigm shift” in the way vitamin D is perceived by clinicians with the hope that more clinicians would embrace its use for the benefit of their practices and patients. For the eleven years following that publication, the key points of that article and its derivatives—including a letter published in the British Medical Journal and a clinical trial published in Journal of Clinical Endocrinology and Metabolism— remain strong, and they have been further supported and extended by the accumulation of additional clinical experience and a wide range of scientific investigations, ranging from in vitro studies, to animal studies, to clinical trials, to epidemiologic studies and meta-analyses. Humans have an absolute requirement for vitamin D3, with catabolic use of approximately 4,000 IU per day for adults, consistent with physiologic production and doses ≥4,000 IU/d used in several successful clinical trials.,,
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