November 05, 2015
(AlignLife.com) Peto’s Paradox and the true cause of cancer is the observation of Professor Richard from the University of Oxford. It says that the incidence of cancer at the species level does not appear to correlate with the number of cells in an organism. For example, incidence of cancer in whales is much lower than the incidence of cancer in humans despite the fact that a whale has thousands of times more cells than a human.
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It is generally accepted that virtually all mammalian cells have a chance of becoming cancerous. If the probability of cancer were fairly constant, one would expect whales to have a much higher incidence of cancer than humans because they have more mammalian cells – but instead the opposite is true. Thus the paradox.
Scientists have put forth various explanations for why this paradox exists – including the speculation that the difference could be due to larger and more slowly dividing cell sizes. However, while there are size differences in some cells between species, the very large majority of the cells of most mammals are similar in size, and the cell division rate is pretty much the same for these similar sized cells. Other scientists have been plowing old familiar territory for mainstream cancer theory by looking at genetics, speculating about genetic changes which may have been part of the “evolution of cancer”.
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