October 17, 2016
(JefferyDachMD.com) We are continually surprised by new studies showing the importance of the microbiome, or “friendly bacteria” colonizing the gut. One such study was done by Dr Ying Taur published in the hematology oncology journal, Blood, in 2014.(1)
Bacterial Diversity Associated with Improved Survival
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Dr Ying Taur studied the “effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation.” He obtained fecal specimens from 80 allogeneic transplant recipients, at time of engraftment. He used bacterial 16S rRNA gene sequencing to characterize microbial diversity classified into high, intermediate, and low diversity. Surprisingly, after three years, over all survival was only 36% for the patients with low diversity, compared to 67% over-all survival for patients with higher microbial diversity. Dr Taur’s conclusion:
In conclusion, the diversity of the intestinal microbiota at engraftment is an independent predictor of mortality in allo-HSCT recipients. These results indicate that the intestinal microbiota may be an important factor in the success or failure in allo-HSCT. (1) (note allo-HSCT =allogeneic stem cell transplant”
Further Studies on Loss of Diversity in Allogeneic Stem Cell Treansplant
Another 2014 study from Dr Holler in Germany confirms Dr Ying’s findings.
